Call of Duty: Black Ops III takes place in 2065, 40 years after the events of Black Ops II, in a world facing upheaval from climate change and new technologies. In response to the drone assaults of Black Ops 2, several countries around the world have developed high-tech air defenses that render conventional air forces virtually useless. As such, most of the warfare between countries is done by covert operatives fighting behind enemy lines. Military technology has progressed to the point where robotics play a major role in combat, and both fully robotic humanoid drones and cyborg supersoldiers have been developed to fight in the battlefield. As a result, there is speculation and fear about an eventual robotic takeover. The game follows a team of black ops soldiers, like previous installments in the Black Ops series.[4]

The campaign stars Christopher Meloni as Commander John Taylor, Katee Sackhoff as Sarah Hall, Sean Douglas as Jacob Hendricks, Rachel Kimsey as Rachel Kane, and Tony Amendola as Dr. Yousef Salim. Ben Browder and Abby Brammell respectively voice the male and female versions of the Player character. Other characters include Ary Katz as Peter Maretti, Rey Gallegos as Sebastian Diaz, Lynn Chen as Goh Xiulan, and Robert Picardo as Sebastian Krueger. Seattle Seahawks running back Marshawn Lynch makes a cameo as a villain.[5][6]

Included in the game is the "Nightmares" campaign mode, which is a retelling of the main campaign with the plot changed to incorporate zombies and other supernatural beings. In this campaign, the lethal Virus 61-15 is released in various cities around the world, turning whoever it infects into zombies. In response, the governments of the world seal off the worst infected areas into Quarantine Zones and form the Deadkillers, cybernetic soldiers trained to exterminate zombies.